Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
Department of Clinical Science and Services, Royal Veterinary College, Hertfordshire, Hatfield, UK.
BMC Vet Res. 2021 Jun 21;17(1):222. doi: 10.1186/s12917-021-02931-9.
Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5-HT receptor antagonists to reduce nausea has been described for chemotherapy, but not for nausea secondary to vestibular disorders.
Sixteen dogs with vestibular syndrome-associated nausea were included in the open-label, multicentre study. The intensity of nausea-like behaviour was analysed before ondansetron administration (0.5 mg/kg i.v.) and 2 h afterwards, using a validated 5-point-scale. The occurrence and frequency of salivation, lip licking, restlessness, vocalisation, lethargy, and vomiting were assessed.
All dogs initially showed signs of nausea, whereas only 31% showed vomitus. The intensity of nausea was significantly reduced in all dogs (p ≤ 0.0001) 2 h after ondansetron administration, including the clinical signs of nausea analysed in 11 dogs (salivation [p = 0.0078], lip licking [p = 0.0078], restlessness [p = 0.0039], and lethargy [p = 0.0078]) except for vocalisation (p > 0.9999).
The results provide preliminary evidence of the potential benefit of ondansetron in the treatment of nausea, which was present in all examined dogs. Vomiting was only observed in 5 dogs indicating that nausea can occur separately and should not be perceived only as a preceding stimulation of the vomiting centre.
前庭综合征常伴有恶心。目前批准用于治疗该疾病的药物是为了止吐而不是止呕。5-羟色胺受体拮抗剂在化疗中减少恶心的疗效已有描述，但尚未用于前庭障碍引起的恶心。
在这项开放性、多中心研究中纳入了 16 只伴有前庭综合征相关恶心的犬。使用经过验证的 5 分制在昂丹司琼（0.5mg/kg，静脉注射）给药前和给药后 2 小时分析似呕行为的强度。评估流涎、舔唇、不安、发声、嗜睡和呕吐的发生和频率。
所有犬最初都表现出恶心的迹象，而只有 31%出现呕物。昂丹司琼给药后 2 小时，所有犬的恶心强度均显著降低（p≤0.0001），包括在 11 只犬中分析的恶心临床体征（流涎[p=0.0078]、舔唇[p=0.0078]、不安[p=0.0039]和嗜睡[p=0.0078]），但发声除外（p＞0.9999）。
这些结果初步证明了昂丹司琼在治疗所有检查犬恶心方面的潜在益处。呕吐仅在 5 只犬中观察到，这表明恶心可以单独发生，而不应该仅仅被视为呕吐中枢的前驱刺激。
