Wagner Sara C, Roskamp Meike, Cölfen Helmut, Böttcher Christoph, Schlecht Sabine, Koksch Beate
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
Org Biomol Chem. 2009 Jan 7;7(1):46-51. doi: 10.1039/b813429d. Epub 2008 Nov 17.
The nanoparticle-peptide interaction described here is based on electrostatic forces and the pH value can act as a trigger to direct the organization of functionalized nanoparticles in a reversible and repeatable manner. The ability of the peptide to interact with the charged gold nanoparticles is directly related to its helical structure and was not found for a random coil peptide with the same net charge. Interestingly, the interaction with nanoparticles seems to induce a fibrillation of the coiled coil peptide.
本文所述的纳米颗粒与肽的相互作用基于静电力，pH值可作为一种触发因素，以可逆且可重复的方式引导功能化纳米颗粒的组装。肽与带电荷的金纳米颗粒相互作用的能力与其螺旋结构直接相关，而具有相同净电荷的无规卷曲肽则不具备这种能力。有趣的是，与纳米颗粒的相互作用似乎会诱导卷曲螺旋肽发生纤维化。
