Conticello Vincent, Hughes Spencer, Modlin Charles
Emory University Chemistry Department, 1515 Dickey Drive, Atlanta, 30322, Georgia.
Subcell Biochem. 2017;82:575-600. doi: 10.1007/978-3-319-49674-0_17.
The development of biomaterials designed for specific applications is an important objective in personalized medicine. While the breadth and prominence of biomaterials have increased exponentially over the past decades, critical challenges remain to be addressed, particularly in the development of biomaterials that exhibit highly specific functions. These functional properties are often encoded within the molecular structure of the component molecules. Proteins, as a consequence of their structural specificity, represent useful substrates for the construction of functional biomaterials through rational design. This chapter provides an in-depth survey of biomaterials constructed from coiled-coils, one of the best-understood protein structural motifs. We discuss the utility of this structurally diverse and functionally tunable class of proteins for the creation of novel biomaterials. This discussion illustrates the progress that has been made in the development of coiled-coil biomaterials by showcasing studies that bridge the gap between the academic science and potential technological impact.
为特定应用设计的生物材料的开发是个性化医疗中的一个重要目标。尽管在过去几十年中生物材料的广度和重要性呈指数级增长，但仍有一些关键挑战有待解决，特别是在开发具有高度特定功能的生物材料方面。这些功能特性通常编码在组成分子的分子结构中。蛋白质由于其结构特异性，通过合理设计成为构建功能性生物材料的有用底物。本章深入探讨了由卷曲螺旋构建的生物材料，卷曲螺旋是目前理解最透彻的蛋白质结构基序之一。我们讨论了这类结构多样且功能可调的蛋白质在创建新型生物材料方面的实用性。通过展示弥合学术科学与潜在技术影响之间差距的研究，本次讨论阐明了卷曲螺旋生物材料开发中所取得的进展。
