一种双功能嵌入剂连接的铜（II）大环化合物的合成与DNA切割活性
Synthesis and DNA cleavage activity of a bifunctional intercalator-linked copper(II) macrocycle.
作者信息
Tseng Ta-Sheng Andrew, Burstyn Judith N
机构信息
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
出版信息
Chem Commun (Camb). 2008 Dec 14(46):6209-11. doi: 10.1039/b812183d. Epub 2008 Oct 27.
Abstract
An intercalator-linked macrocycle 3,6-bis(dimethylamino)-10-(6-[1,4,7-triazacyclononane]hexyl) acridinium bromide was synthesized, its copper(ii) complex was prepared, and the DNA cleavage activity of this metal complex was compared to that of the intercalator-free (Cu[9]aneN(3))(2+) complex.
摘要
合成了一种嵌入剂连接的大环化合物3,6-双（二甲氨基）-10-（6-[1,4,7-三氮杂环壬烷]己基）吖啶鎓溴化物，制备了其铜（II）配合物，并将该金属配合物的DNA切割活性与无嵌入剂的（Cu[9]aneN(3)）(2+)配合物的活性进行了比较。
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