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糖尿病控制不佳合并真菌性全鼻窦炎伴严重视力丧失

Fungal pan-sinusitis with severe visual loss in uncontrolled diabetes.

作者信息

Chua Jocelyn L L, Cullen James F

机构信息

Singapore National Eye Centre, Singapore.

出版信息

Ann Acad Med Singap. 2008 Nov;37(11):964-7.

Abstract

INTRODUCTION

Invasive fungal pan-sinusitis can present atypically with severe acute visual loss with minimal anterior orbital inflammation. We describe 2 such cases with a background of uncontrolled diabetes.

CLINICAL PICTURE

Respective clinical presentations of orbital apex and cavernous sinus syndromes were associated with isolation of Aspergillus galactomannan and Rhizopus.

TREATMENT

Urgent extensive surgical debridement and systemic antifungal is necessary.

OUTCOME

Clinical improvement of the ocular motor nerves can be expected within 2 months of treatment but visual loss is usually permanent.

CONCLUSION

Underlying pansinusitis is an important differential for acute visual loss, especially in uncontrolled diabetics. Early treatment determines outcome.

摘要

引言

侵袭性真菌性全鼻窦炎可能表现不典型,伴有严重急性视力丧失且眶前部炎症轻微。我们描述2例有血糖控制不佳背景的此类病例。

临床表现

眶尖综合征和海绵窦综合征的各自临床表现分别与半乳甘露聚糖曲霉和根霉的分离有关。

治疗

紧急进行广泛手术清创和全身抗真菌治疗是必要的。

结果

治疗后2个月内眼运动神经有望临床改善,但视力丧失通常是永久性的。

结论

潜在的全鼻窦炎是急性视力丧失的重要鉴别诊断因素,尤其是在血糖控制不佳的糖尿病患者中。早期治疗决定预后。

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