Almeida-Pititto Bianca de, Almada Filho Clineu de M, Cendoroglo Maysa S
Departamento de Medicina Preventiva, EPM, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Arq Bras Endocrinol Metabol. 2008 Oct;52(7):1076-83. doi: 10.1590/s0004-27302008000700003.
As the population getting older, the chronic diseases will be more prevalent as diabetes mellitus (DM) and diseases characterized by cognitive deficits, as dementia. Studies have already shown an association between DM and cardiovascular risk factors associated with cognitive impairment. Besides the vascular complications of DM, studies have proposed the role of hyperglycemia and advanced glycosilation end products (AGEP) causing oxidative stress and beta-amyloid protein brain deposition. Other factors have also been investigated, such as the role of insulinemia, genetic and IGF-1 (insulin-like growth factor-1). Some studies showed that good glucose control and intake of polyunsaturated fat, Omega-3 or anti-oxidative food can play a protector role against cognitive deficits. Improving knowledge about the association between DM and cognition and its physiopathology, can be essential for the prevention and treatment of cognitive impairment, leading to a beneficial impact on the quality of life of elderly patients with DM.
随着人口老龄化，慢性病如糖尿病（DM）以及以认知缺陷为特征的疾病如痴呆症将更为普遍。研究已经表明糖尿病与认知障碍相关的心血管危险因素之间存在关联。除了糖尿病的血管并发症外，研究还提出高血糖和晚期糖基化终产物（AGEP）会导致氧化应激和β-淀粉样蛋白在脑内沉积。其他因素也已得到研究，如胰岛素血症、遗传因素和胰岛素样生长因子-1（IGF-1）的作用。一些研究表明，良好的血糖控制以及摄入多不饱和脂肪、欧米伽-3或抗氧化食物可对认知缺陷起到保护作用。增进对糖尿病与认知及其病理生理学之间关联的认识，对于预防和治疗认知障碍至关重要，会对老年糖尿病患者的生活质量产生有益影响。
