Solov'eva E Yu, Dzhutova E D, Knyazeva V S
Pirogov Russian National Research Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(7):85-93. doi: 10.17116/jnevro20161167185-93.
The article presents the currents concepts on the mechanisms of brain lesions and development of cognitive impairment in diabetes mellitus (DM) including DM type 2. Metabolic and vascular mechanisms, oxidative stress, hyperglycemia, glutamate excitotoxicity, insulin insufficiency and brain insulin resistance, general vascular and microcirculatory disturbances, death of cortical neurons, decrease in the newly synthesized acetylcholine, activation of lipid peroxidation are considered. A review of the main domestic and international drugs used in clinical practice for treatment of cognitive impairment in patients with DM is presented.
本文介绍了包括2型糖尿病在内的糖尿病（DM）患者脑损伤机制及认知障碍发展的当前概念。文中考虑了代谢和血管机制、氧化应激、高血糖、谷氨酸兴奋性毒性、胰岛素不足和脑胰岛素抵抗、全身血管和微循环紊乱、皮质神经元死亡、新合成乙酰胆碱减少以及脂质过氧化激活等因素。本文还综述了临床实践中用于治疗糖尿病患者认知障碍的主要国内外药物。
