Santos Vanessa Prado dos, Caffaro Roberto Augusto, Pozzan Geanete, Saieg Mauro Ajaj, Castelli Júnior Valter
School of Medical Sciences, Santa Casa de São Paulo, São Paulo, SP, Brazil.
Arq Bras Endocrinol Metabol. 2008 Oct;52(7):1115-23. doi: 10.1590/s0004-27302008000700007.
To perform a comparative analysis of atherosclerotic lesions and capillaries changes in diabetic and nondiabetic patients.
Leg arteries and skin of 57 amputated lower limbs of diabetic (47.3%) and nondiabetic patients were histologically examined. The percentage of arterial stenosis of infrapopliteal arteries and the histological classification of atherosclerotic lesions were determined. Capillary thickening was classified into four categories.
Diabetic group showed more than 75% stenosis in 57% (vs. 56% in nondiabetic) of the anterior tibial; 78% (vs. 68%) of the posterior tibial; 58% (vs. 50%) of the peroneal leg arteries. Diabetic and nondiabetic patients have predominance of type VI atherosclerotic lesions. The comparison of both groups showed no significant differences in atherosclerotic lesions. Diabetic patients had significantly more PAS positive capillary thickening (63% vs. 23%).
There were no differences in histological characteristics of atherosclerosis between the two groups. Capillary thickening has been more observed in diabetics.
对糖尿病患者和非糖尿病患者的动脉粥样硬化病变及毛细血管变化进行对比分析。
对57例糖尿病患者（47.3%）和非糖尿病患者截肢的下肢的腿部动脉和皮肤进行组织学检查。确定腘动脉以下动脉狭窄的百分比以及动脉粥样硬化病变的组织学分类。毛细血管增厚分为四类。
糖尿病组胫前动脉有57%出现超过75%的狭窄（非糖尿病组为56%）；胫后动脉为78%（非糖尿病组为68%）；腓动脉为58%（非糖尿病组为50%）。糖尿病患者和非糖尿病患者均以VI型动脉粥样硬化病变为主。两组动脉粥样硬化病变的比较无显著差异。糖尿病患者PAS阳性的毛细血管增厚明显更多（63%对23%）。
两组间动脉粥样硬化的组织学特征无差异。糖尿病患者中毛细血管增厚更为常见。
