Lankford M F, Roscoe A K, Pennington S N, Myers R D
Department of Pharmacology, School of Medicine, East Carolina University, Greenville 27858.
Alcohol. 1991 Jul-Aug;8(4):293-9. doi: 10.1016/0741-8329(91)90417-u.
A genetically based animal model of alcoholism has been characterized in Wistar-derived rats in terms of their preference (P rats) or lack of preference (NP rats) for 10% ethanol over water. The present experiments were designed to determine: 1) whether a 10% solution of ethanol is the optimal concentration for differentiation of these lines; 2) what concentrations of ethanol are maximally preferred by P and NP rats; and 3) whether highly palatable fluids presented simultaneously with each rat's preferred solution of ethanol would alter the patterns of drinking by either the P or NP or both lines of rats. A three-bottle procedure was used to establish preference for ethanol in the presence of water as well as highly palatable solutions. The results showed that, when concentrations ranging from 3-30% were presented over a 12-day test interval, the mean absolute intake of ethanol of the P rats was 6.7 g/kg per day, with a maximum intake of 10.9 g/kg per day at the 25% concentration. These levels of intake were significantly higher than the 4.3 g/kg per day consumed during the presentation of the commonly used constant concentration of 10%. Similarly, the mean absolute intake of ethanol by the NP rats was also elevated significantly at concentrations of 15-30% (2.0 g/kg per day) above that consumed at the 10% concentration (0.4 g/kg).(ABSTRACT TRUNCATED AT 250 WORDS)
一种基于基因的酒精中毒动物模型已在源自Wistar的大鼠中得以表征，依据它们对10%乙醇相对于水的偏好（P大鼠）或无偏好（NP大鼠）。本实验旨在确定：1）10%乙醇溶液是否是区分这些品系的最佳浓度；2）P大鼠和NP大鼠最偏好的乙醇浓度是多少；3）与每只大鼠偏好的乙醇溶液同时呈现的高度可口液体是否会改变P大鼠或NP大鼠或两者的饮酒模式。采用三瓶法在有水以及高度可口溶液存在的情况下确定对乙醇的偏好。结果表明，在12天的测试期间呈现3% - 30%的浓度范围时，P大鼠乙醇的平均绝对摄入量为每天6.7克/千克，在25%浓度时最大摄入量为每天10.9克/千克。这些摄入量水平显著高于呈现常用恒定浓度10%时每天消耗的4.3克/千克。同样，NP大鼠在15% - 30%浓度（每天2.0克/千克）时乙醇的平均绝对摄入量也比10%浓度（每天0.4克/千克）时消耗的量显著升高。（摘要截短于250字）
