Backes Danielle M, Kurman Robert J, Pimenta Jeanne M, Smith Jennifer S
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2103 McGavran-Greenberg Hall, Campus Box# 7435, Chapel Hill, NC 27599-7435, USA.
Cancer Causes Control. 2009 May;20(4):449-57. doi: 10.1007/s10552-008-9276-9. Epub 2008 Dec 11.
Type-specific prevalence data of human papillomavirus (HPV) DNA in penile carcinoma are needed to determine the potential impact of HPV prophylactic vaccines, assuming demonstrated efficacy in men.
A review was conducted using search terms including HPV and penile cancer. Studies using polymerase chain reaction (PCR) assays for HPV DNA detection in invasive penile carcinoma were included.
A total of 1,266 squamous cell carcinoma (SCC) cases contributed data from 30 studies. The number of SCC was similar in Europe (28.2%), North America (27.6%), South America (23.9%) and Asia (20.4%). All SCC were histologically confirmed with biopsies for DNA detection. Most commonly used PCR primers were type-specific (35.2%), and combination PCR (18.2%). HPV prevalence was 47.9%, ranging from 22.4% in verrucous SCC to 66.3% for the basaloid/warty subtypes. HPV16 (30.8%), HPV6 (6.7%) and HPV18 (6.6%) were the most prevalent types. HPV16 and/or HPV 18 prevalence was 36.7%.
HPV DNA was detected in half of SCC, with HPV16 being the most common type. If proven efficacious in men, prophylactic vaccines targeting carcinogenic types HPV16 and 18 could potentially reduce approximately one-third of incident SCC.
假设人乳头瘤病毒（HPV）预防性疫苗对男性有效，需要阴茎癌中HPV DNA的型特异性流行率数据来确定其潜在影响。
使用包括HPV和阴茎癌在内的检索词进行综述。纳入使用聚合酶链反应（PCR）检测浸润性阴茎癌中HPV DNA的研究。
共有1266例鳞状细胞癌（SCC）病例的数据来自30项研究。欧洲（28.2%）、北美（27.6%）、南美（23.9%）和亚洲（20.4%）的SCC病例数相似。所有SCC均经组织学活检确诊以进行DNA检测。最常用的PCR引物是型特异性引物（35.2%）和联合PCR（18.2%）。HPV流行率为47.9%，从疣状SCC中的22.4%到基底样/疣状亚型中的66.3%不等。HPV16（30.8%）、HPV6（6.7%）和HPV18（6.6%）是最常见的类型。HPV16和/或HPV18的流行率为36.7%。
在一半的SCC中检测到HPV DNA，其中HPV16是最常见的类型。如果证明对男性有效，针对致癌型HPV16和18的预防性疫苗可能会使约三分之一的新发SCC病例数减少。
