Devaskar U P, deMello D E, Ackerman J
Department of Pediatrics and Pathology, St. Louis University School of Medicine, Cardinal Glennon Children's Hospital, Mo.
Biol Neonate. 1991;59(6):346-51. doi: 10.1159/000243370.
Though maternal treatment with thyrotropin-releasing hormone (TRH) for prevention of hyaline membrane disease has been utilized, precise mechanisms of TRH in accelerating fetal lung maturation remain unclear. We studied the effect of maternally administered TRH or DN1417 (an analog of TRH) on functional and morphologic fetal rabbit lung maturation and the duration of survival after premature delivery. Because DN1417 retains the neurotransmitter but not the neuroendocrine effects of TRH, this study enables us to determine which of these effects was responsible for enhancement of lung maturation. TRH or DN1417 (0.2 mg/kg/dose) or saline was injected intravenously into New Zealand White rabbit does 48, 36, 24, 12 and 2 h prior to sacrifice on day 27 of gestation. Functional pulmonary maturity was assessed by pressure-volume hysteresis, and morphologic maturity was assessed by histologic technique. Maternal administration of TRH or DN1417 enhanced both functional and morphologic fetal lung maturation as well as the duration of neonatal survival after premature delivery. We propose that the effect of TRH in fetal lung maturation is due to neurotransmitter rather than neuroendocrine effects.
尽管已采用促甲状腺激素释放激素（TRH）对母体进行治疗以预防透明膜病，但TRH加速胎儿肺成熟的确切机制仍不清楚。我们研究了母体给予TRH或DN1417（TRH的一种类似物）对早产兔胎儿肺功能和形态成熟以及存活时间的影响。由于DN1417保留了TRH的神经递质作用但不具有神经内分泌作用，本研究使我们能够确定这些作用中哪一种对肺成熟的增强负责。在妊娠第27天处死前48、36、24、12和2小时，将TRH或DN1417（0.2mg/kg/剂量）或生理盐水静脉注射到新西兰白兔母兔体内。通过压力-容积滞后评估肺功能成熟度，通过组织学技术评估形态成熟度。母体给予TRH或DN1417可增强早产兔胎儿肺的功能和形态成熟以及新生儿存活时间。我们认为，TRH对胎儿肺成熟的作用是由于神经递质作用而非神经内分泌作用。
