Devaskar U, Nitta K, Szewczyk K, Sadiq H F, deMello D
Am J Obstet Gynecol. 1987 Aug;157(2):460-4. doi: 10.1016/s0002-9378(87)80195-3.
We investigated the effect of maternally administered thyrotropin-releasing hormone on functional and morphologic fetal lung maturation. Thyrotropin-releasing hormone (40 micrograms/kg/day) or the vehicle was injected intravenously into the New Zealand White rabbit does on days 25, 26, and 27 of gestation. On day 27 of pregnancy, the does were killed and the fetuses were delivered. The functional pulmonary maturity was assessed by pressure-volume hysteresis while morphologic maturity was assessed by histologic techniques. Enhanced functional and morphologic fetal lung maturation was noted in animals treated with thyrotropin-releasing hormone when compared with controls. An important role of thyrotropin-releasing hormone in fetal lung maturation is proposed.
我们研究了母体给予促甲状腺激素释放激素对胎儿肺功能和形态成熟的影响。在妊娠第25、26和27天，将促甲状腺激素释放激素（40微克/千克/天）或赋形剂静脉注射到新西兰白兔母兔体内。在妊娠第27天，处死母兔并娩出胎儿。通过压力-容积滞后评估肺功能成熟度，通过组织学技术评估形态成熟度。与对照组相比，用促甲状腺激素释放激素治疗的动物胎儿肺功能和形态成熟增强。提出促甲状腺激素释放激素在胎儿肺成熟中起重要作用。
