Brufau Gemma, Canela Miguel Angel, Rafecas Magda
Department of Nutrition and Food Science, CeRTA (Nutrició i Salut), University of Barcelona, 08028 Barcelona, Spain.
Nutr Res. 2008 Apr;28(4):217-25. doi: 10.1016/j.nutres.2008.02.003.
The aim of this review is to give a general contemporary overview of the physiologic effects of phytosterols and their role in cholesterol uptake in the intestinal tract. The mechanism of phytosterols action is based on its ability to reduce cholesterol absorption. Doses of 0.8 to 4.0 g/d of phytosterols were used to reduce low-density lipoprotein cholesterol concentrations by 10% to 15%, although most of the studies described used 2 g/d of phytosterol to achieve a reduction of 10% in low-density lipoprotein cholesterol concentrations. Although some studies point to the possibility that elevated plasma phytosterol concentrations could contribute to the development of premature coronary artery diseases, extensive safety evaluation studies have been conducted for these compounds, and they have been considered safe.
本综述的目的是对植物甾醇的生理效应及其在肠道胆固醇摄取中的作用进行当代的全面概述。植物甾醇的作用机制基于其降低胆固醇吸收的能力。使用0.8至4.0克/天的植物甾醇剂量可使低密度脂蛋白胆固醇浓度降低10%至15%，不过大多数所描述的研究使用2克/天的植物甾醇来使低密度脂蛋白胆固醇浓度降低10%。尽管一些研究指出血浆植物甾醇浓度升高可能促成早发性冠状动脉疾病的发展，但已针对这些化合物进行了广泛的安全性评估研究，并且它们被认为是安全的。
