Fontdevila Joan, Serra-Renom Jose Maria, Raigosa Mauricio, Berenguer Joan, Guisantes Eva, Prades Eduardo, Benito-Ruiz Jesus, Martinez Esteban
Department of Plastic Surgery, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Aesthet Surg J. 2008 Jul-Aug;28(4):380-6. doi: 10.1016/j.asj.2008.05.002.
Autologous fat transplantation for soft tissue augmentation is a commonly used technique without a universally accepted approach. The literature includes a variety of reports describing varying degrees of success or failure.
To evaluate the behavior of facial fat grafts in humans with the use of an objective measuring tool.
A prospective randomized study, comparing patients pre- and postoperatively, was designed to evaluate the long-term viability of fat grafting. Participants were 18 men and 8 women between 34 and 59 years of age (mean, 45.07 yrs; standard deviation, 6.54 yrs). A total of 52 hemifaces in 26 patients diagnosed with HIV and demonstrating facial lipoatrophy were treated with fat transplantation using Coleman's technique. HIV-positive patients were chosen as study participants because their nearly total lack of subcutaneous fat diminishes the bias in the evaluation of fat volume. Fat graft viability was evaluated by measuring the volume of adipose tissue evolution via computed tomography scan before fat grafting, at the second month after fat grafting, and 1 year after fat grafting. Descriptive statistical analysis was performed.
The mean volume on the right and left cheeks before fat grafting was 1.57 cc. The mean volume 2 months after the procedure was 2.93 cc with a statistically significant mean increase of 1.36 cc (P < .001) between baseline and the second month after the procedure. The mean volume after 12 months was 3.29 cc (P < .001), with a mean increase compared with the baseline of 1.72 cc, and of 0.36 cc between months 2 and 12. The statistically significant posttreatment improvement (P < .001) was maintained until month 12 of the follow-up period.
Using objective measurement, this study demonstrates that with one fat grafting procedure a durable result can be achieved, persisting for a minimum of 12 months without any trend towards reabsorption.
自体脂肪移植用于软组织填充是一种常用技术，但尚无普遍接受的方法。文献中有各种描述不同程度成功或失败的报道。
使用客观测量工具评估人体面部脂肪移植的情况。
设计一项前瞻性随机研究，对患者进行术前和术后比较，以评估脂肪移植的长期存活率。参与者为18名男性和8名女性，年龄在34至59岁之间（平均45.07岁；标准差6.54岁）。采用科尔曼技术，对26例诊断为HIV且有面部脂肪萎缩的患者的52个半侧面部进行脂肪移植治疗。选择HIV阳性患者作为研究参与者，因为他们几乎完全缺乏皮下脂肪，可减少脂肪体积评估中的偏差。通过在脂肪移植前、脂肪移植后第二个月以及脂肪移植后1年进行计算机断层扫描测量脂肪组织的体积变化，来评估脂肪移植的存活率。进行描述性统计分析。
脂肪移植前左右脸颊的平均体积为1.57立方厘米。术后2个月的平均体积为2.93立方厘米，与基线相比，平均增加1.36立方厘米，差异有统计学意义（P <.001）。12个月后的平均体积为3.29立方厘米（P <.001），与基线相比平均增加1.72立方厘米，2至12个月间平均增加0.36立方厘米。在随访期的第12个月，治疗后的改善仍具有统计学意义（P <.001）。
本研究通过客观测量表明，单次脂肪移植手术可取得持久效果，至少持续12个月且无任何吸收趋势。
