Goldman Alberto, Gotkin Robert H, Sarnoff Deborah S, Prati Clarissa, Rossato Flávia
Aesthet Surg J. 2008 Nov-Dec;28(6):656-62. doi: 10.1016/j.asj.2008.09.002.
Cellulite is an alteration of the topography of the skin that occurs in body areas where fat deposition seems to be under the influence of estrogen: mainly the hips, buttocks, thighs, and abdomen. The presence of cellulite is a significant source of patient dissatisfaction. There is currently no cure or consistently effective treatment for cellulite.
The authors sought to show that the subdermal application of the neodymium-doped yttrium aluminium garnet (Nd:YAG) laser combined with autologous fat transplantation is a safe and effective treatment for cellulite.
From January 2003 to December 2006, 52 female patients with Curri grade III to IV cellulite were treated with subdermal 1064-nm Nd:YAG laser lipolysis combined with autologous fat transplantation. Patient assessment was collected for data analysis. After the treatment, tissue samples were obtained in some subjects in order to ascertain the histologic effects of the laser treatment.
This treatment resulted in significant clinical improvement in cellulite. The adverse effects were mild and temporary, and the postoperative period was well tolerated. A majority of patients (84.6%) rated the results of treatment as either good or excellent.
The treatment of severe cases of cellulite (Curri grades III and IV) by a combination of 1064-nm Nd:YAG laser lipolysis and autologous fat transplantation proved to be both safe and effective. In addition, subdermal laser lipolysis has the advantage of inducing neocollagenesis and stimulating postoperative skin tightening. This represents a new treatment option for the ubiquitous cellulite disorder. Although this treatment has shown promising results in this pilot study, further studies are necessary in order to draw final conclusions.
橘皮组织是皮肤表面形态的一种改变，出现在脂肪沉积似乎受雌激素影响的身体部位：主要是臀部、臀部、大腿和腹部。橘皮组织的存在是患者不满的一个重要来源。目前尚无治愈橘皮组织或始终有效的治疗方法。
作者试图证明，皮下应用掺钕钇铝石榴石（Nd:YAG）激光联合自体脂肪移植是一种治疗橘皮组织的安全有效方法。
从2003年1月至2006年12月，对52例Curri III至IV级橘皮组织的女性患者进行了皮下1064nm Nd:YAG激光脂肪分解联合自体脂肪移植治疗。收集患者评估数据进行分析。治疗后，在一些受试者中获取组织样本，以确定激光治疗的组织学效果。
该治疗使橘皮组织有显著的临床改善。不良反应轻微且为暂时性，术后耐受性良好。大多数患者（84.6%）对治疗结果的评价为良好或优秀。
1064nm Nd:YAG激光脂肪分解与自体脂肪移植联合治疗重度橘皮组织（Curri III级和IV级）被证明是安全有效的。此外，皮下激光脂肪分解具有诱导新胶原形成和刺激术后皮肤紧致的优点。这代表了一种针对普遍存在的橘皮组织疾病的新治疗选择。尽管该治疗在这项初步研究中显示出有前景的结果，但为了得出最终结论，仍需要进一步研究。
