Department of Medicine, Section of Infectious Diseases, University of Ottawa, Ottawa, Ontario, Canada.
Foot Ankle Surg. 2008;14(2):74-81. doi: 10.1016/j.fas.2007.10.006. Epub 2007 Dec 26.
Diabetic foot ulcers are a major cause of morbidity and mortality. This study evaluated the clinical outcomes in Canadian non-Aboriginal and Aboriginal diabetic patients with foot ulcers managed at a multidisciplinary, tertiary care diabetic foot clinic.
A retrospective review of medical records was done for 325 patients receiving care during a 2-year period. All patients were followed at least 1 year after the initial visit.
There were 224 (69%) non-Aboriginal and 101 (31%) Aboriginal patients with 697 foot ulcers. At the initial office visit, 204 (63%) patients had lesions in Wagner grades 2-4. At the most recent evaluation (average, 79+/-73 weeks after initial clinic visit), 190 (58%) patients were rated as having a good outcome (either healed or healing), but a poor outcome (static, progression, amputation, or death) was noted in 135 (42%) patients. At the most recent evaluation, the majority of the 697 ulcers that were noted at the initial or subsequent clinic visits were healed. Aboriginal patients had a shorter average time from initial clinic visit to major lower extremity amputation (Aboriginal, 50+/-64 weeks; non-Aboriginal, 62+/-56 weeks; P<0.01). Residence in a rural or reserve community also correlated with shorter average time from initial clinic visit to major lower extremity amputation (rural or reserve, 45+/-56 weeks; urban, 66+/-61 weeks; P<0.002). When controlled for non-urban residence, Aboriginal ethnicity was not associated with poorer clinical outcome. Earlier major lower extremity amputation was significantly associated with non-urban residence, Aboriginal ethnicity, and arterial insufficiency. Poor clinical outcome was significantly associated with being referred with a lesion present, age greater than 60 years, prior lower extremity amputation or revascularization, arterial insufficiency, more than one lesion on initial presentation, longer duration of type 2 diabetes, and a higher initial Wagner grade for the most advanced lesion.
A multidisciplinary diabetic foot clinic may be successful in treating diabetic foot ulcers in Aboriginal and non-Aboriginal people. However, the frequency of poor outcome is high, consistent with the high prevalence of associated significant risk factors in this population.
糖尿病足溃疡是发病率和死亡率的主要原因。本研究评估了在多学科三级保健糖尿病足诊所接受治疗的加拿大非原住民和原住民糖尿病患者的临床结局。
对 2 年内接受治疗的 325 名患者的病历进行了回顾性分析。所有患者在初次就诊后至少随访 1 年。
224 名(69%)为非原住民,101 名(31%)为原住民,共有 697 处足部溃疡。初次就诊时,204 名(63%)患者的病变处于 Wagner 分级 2-4 级。在最近一次评估(平均初次就诊后 79+/-73 周)时,190 名(58%)患者的结果评为良好(愈合或正在愈合),但 135 名(42%)患者的结果为较差(稳定、进展、截肢或死亡)。在最近一次评估时,大多数在初次或随后的就诊时发现的 697 处溃疡已愈合。原住民从初次就诊到主要下肢截肢的平均时间较短(原住民,50+/-64 周;非原住民,62+/-56 周;P<0.01)。居住在农村或保留地社区也与从初次就诊到主要下肢截肢的平均时间较短相关(农村或保留地,45+/-56 周;城市,66+/-61 周;P<0.002)。当控制非城市居住时,原住民种族与较差的临床结局无关。较早的主要下肢截肢与非城市居住、原住民种族和动脉功能不全显著相关。较差的临床结局与就诊时存在病变、年龄大于 60 岁、既往下肢截肢或血运重建、动脉功能不全、初次就诊时有多个病变、2 型糖尿病病程较长以及最严重病变的初始 Wagner 分级较高显著相关。
多学科糖尿病足诊所可能成功治疗原住民和非原住民的糖尿病足溃疡。然而,不良结局的频率很高,与该人群中相关重要危险因素的高患病率一致。