哥伦比亚中西部15个短串联重复序列（STR）基因座的遗传多态性
Genetic polymorphism of 15 STR loci in central western Colombia.
作者信息
Porras L, Beltrán L, Ortiz T, Sanchez-Diz P, Carracedo A, Henao J
机构信息
Medical Genetic Laboratory of Universidad Tecnológica de Pereira, Colombia.
出版信息
Forensic Sci Int Genet. 2008 Jan;2(1):e7-8. doi: 10.1016/j.fsigen.2007.08.004. Epub 2007 Sep 17.
Fifteen autosomal short tandem repeat (STR) loci were analyzed using the AmpFISTR Identifiler PCR Amplification Kit in 1944 samples of healthy unrelated individuals, born in the regions of Caldas, Quindio and Risaralda, Colombia. Allele frequencies and statistical parameters of forensic interest are presented for all markers (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, THO1, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA). All loci of the pooled data were in agreement with Hardy-Weinberg equilibrium, after Bonferroni correction. Comparisons with neighboring Latin American populations and Andalucia (Spain) revealed significant differences in allele distributions. Genetic data presented in this study can be used for routine forensic applications in the region.
使用AmpFISTR Identifiler PCR扩增试剂盒，对1944例出生于哥伦比亚卡尔达斯、金迪奥和里萨拉尔达地区的健康无关个体样本进行了15个常染色体短串联重复序列（STR）位点分析。给出了所有标记（D8S1179、D21S11、D7S820、CSF1PO、D3S1358、THO1、D13S317、D16S539、D2S1338、D19S433、vWA、TPOX、D18S51、D5S818和FGA）的等位基因频率和法医学相关的统计参数。经Bonferroni校正后，汇总数据的所有位点均符合哈迪-温伯格平衡。与邻近拉丁美洲人群和安达卢西亚（西班牙）的比较显示，等位基因分布存在显著差异。本研究提供的遗传数据可用于该地区的常规法医鉴定。
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