Romero Rosa Elena, Briceño Ignacio, Lizarazo Rocío del Pilar, Willuweit Sascha, Roewer Lutz, Gómez Alberto
Grupo de Genética Forense, Instituto Nacional de Medicina Legal y Ciencias Forenses, Bogotá, Colombia.
Forensic Sci Int Genet. 2008 Mar;2(2):e5-8. doi: 10.1016/j.fsigen.2007.09.005. Epub 2007 Nov 26.
Allelic frequencies and haplotypic composition of 305 male unrelated individuals from the Caribbean Colombian states of Atlántico, Bolívar, Cesar, Córdoba, Guajira, Magdalena and Sucre, were determined using 16 Y-chromosome STR loci. Two hundred and ninety three (293) haplotypes were identified, of which 283 were unique and the other 10 were found twice or thrice in the Caribbean population tested. Haplotypic diversity surpassed the values obtained in other populations, ranging from 99.66% in the population of Sucre to 99.99% in the population of Córdoba. We also calculated the overall haplotypic diversity (99.97%) and the discrimination power of these haplotypes (96.1%) in these groups. Analysis of molecular variance (AMOVA) for 10 Colombian and Spanish populations (3139 haplotypes) reveals low differentiation between the Colombian populations of mainly European descent and large distance to Afroamerican populations living in Colombia.
使用16个Y染色体STR基因座，确定了来自加勒比地区哥伦比亚的大西洋省、玻利瓦尔省、塞萨尔省、科尔多瓦省、瓜希拉省、马格达莱纳省和苏克雷省的305名无血缘关系男性个体的等位基因频率和单倍型组成。共鉴定出293种单倍型，其中283种是独特的，另外10种在测试的加勒比人群中出现了两次或三次。单倍型多样性超过了在其他人群中获得的值，从苏克雷省人群的99.66%到科尔多瓦省人群的99.99%不等。我们还计算了这些群体中的总体单倍型多样性（99.97%）和这些单倍型的鉴别力（96.1%）。对10个哥伦比亚和西班牙人群（3139种单倍型）进行的分子方差分析（AMOVA）显示，主要为欧洲血统的哥伦比亚人群之间的分化程度较低，但与生活在哥伦比亚的非裔美国人种群距离较远。
