Amorim António
IPATIMUP, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Portugal.
Forensic Sci Int Genet. 2008 Sep;2(4):376-8. doi: 10.1016/j.fsigen.2008.04.001. Epub 2008 May 15.
The combination of the information obtained from lineage genetic markers, such as mitochondrial DNA (mtDNA) and the non-homologous region of Y-chromosome, with data resulting from meiotically recombining loci (diploid/autosomal or haplodiploid/X chromosome) into a single likelihood ratio has been recently proposed. In this work we challenge this proposal and demonstrate that while the genetic evidence obtained from loci which reshuffle at meiosis is appropriate for individual probability calculations, mtDNA and Y-chromosome data are not and, consequently, that joining the evidential value of the two types of markers is generally inconsistent and should be avoided. The assumption of non-involvement of relatives must be clearly and explicitly stated and its acceptance must be left to the court decision.
最近有人提出，将从线粒体DNA（mtDNA）和Y染色体非同源区域等谱系遗传标记中获得的信息，与减数分裂重组基因座（二倍体/常染色体或单倍二倍体/X染色体）产生的数据合并为单一似然比。在这项工作中，我们对这一提议提出质疑，并证明虽然从减数分裂时重新组合的基因座获得的遗传证据适用于个体概率计算，但mtDNA和Y染色体数据并不适用，因此，将这两种标记的证据价值结合起来通常是不一致的，应该避免。必须明确且清晰地说明亲属未参与的假设，并且是否接受该假设应由法院决定。
