肿瘤细胞中单价阳离子的细胞内比率（Na+/K+）以及基因的转录活性。
Intracellular ratio between monovalent cations (Na+/K+), and transcriptional activity of genes in tumour cells.
作者信息
Kaz'min S D, Danko I M, Bukavina N V, Kolosov E V
机构信息
R. E. Kavetsky Institute for Oncology Problems, Academy of Sciences of the Ukrainian SSR, Kiev.
出版信息
Folia Biol (Praha). 1991;37(2):77-86.
The effects of the intracellular Na+/K+ ratio on transcriptional activity of ribosomal, c-fos, beta-actin and histone genes of Ehrlich ascites tumour cells and P-388 leukaemia cells have been investigated. Optimum values of the Na+/K+ ratio for selective transcription of genes are shown, they are in accordance with the Na+/K+ ratio and mRNA content of respective genes during the cell cycle. Differential activation and repression of these genes do not correlate with the total synthesis rate of RNA during the cell cycle. The data indicate a selective nature of the action of monovalent cations on gene expression during the cell growth.
研究了细胞内Na⁺/K⁺比值对艾氏腹水瘤细胞和P - 388白血病细胞核糖体、c - fos、β - 肌动蛋白和组蛋白基因转录活性的影响。结果显示了基因选择性转录的Na⁺/K⁺比值最佳值，它们与细胞周期中各基因的Na⁺/K⁺比值和mRNA含量一致。这些基因的差异激活和抑制与细胞周期中RNA的总合成速率无关。数据表明单价阳离子在细胞生长过程中对基因表达的作用具有选择性。
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