[细胞内钠钾比 对白血病P-388和艾氏腹水癌细胞中c-fos癌基因及β-肌动蛋白基因表达的影响]
[Effects of intracellular Na+/K+ ratio on expression of c-fos oncogene and beta-actin gene in ascitic cells of leukemia P-388 and Ehrlich tumor].
作者信息
Smirnova N V, Danko I M, Kolosov E V, Kaz'min S D
出版信息
Eksp Onkol. 1990;12(4):31-5.
The intracellular Na+/K+ ratio was studied for its effect on expression gene beta-actin and oncogene c-fos and activity of these genes during the mitotic cycle in ascites cells of leukemia P-388 and Ehrlich tumour. It was established that gene beta-actin was activated at high and low ratios of Na+/K+, while c-fos only at high ones. The expression of these genes during the mitotic cell cycle was due to changes in the intracellular Na+/K+ ratio. The obtained data showed an important role of intracellular homeostasis of monovalent cations in regulation of gene expression during the mitotic cell cycle.
研究了白血病P - 388腹水细胞和艾氏腹水癌细胞有丝分裂周期中细胞内Na⁺/K⁺比值对β - 肌动蛋白基因和癌基因c - fos表达及其基因活性的影响。结果表明，在高和低Na⁺/K⁺比值时β - 肌动蛋白基因均被激活，而c - fos仅在高Na⁺/K⁺比值时被激活。这些基因在有丝分裂细胞周期中的表达归因于细胞内Na⁺/K⁺比值的变化。所得数据表明，单价阳离子的细胞内稳态在有丝分裂细胞周期基因表达调控中起重要作用。
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