构建不对称的大脑：斑马鱼上丘脑的发育
Building an asymmetric brain: development of the zebrafish epithalamus.
作者信息
Snelson Corey D, Gamse Joshua T
机构信息
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
出版信息
Semin Cell Dev Biol. 2009 Jun;20(4):491-7. doi: 10.1016/j.semcdb.2008.11.008. Epub 2008 Nov 25.
Abstract
The human brain exhibits notable asymmetries. Little is known about these symmetry deviations; however scientists are beginning to understand them by employing the lateralized zebrafish epithalamus as a model. The zebrafish epithalamus consists of the pineal and parapineal organs and paired habenular nuclei located bilateral to the pineal complex. While zebrafish pineal and parapineal organs arise from a common population of cells, parapineal cells undergo a separate program that allows them to migrate left of the pineal anlage. Studying the processes that lead to brain laterality in zebrafish will allow a better understanding of how human brain laterality is established.
摘要
人类大脑呈现出显著的不对称性。关于这些对称性偏差，人们所知甚少；然而，科学家们正开始通过将侧化的斑马鱼上丘脑作为模型来理解它们。斑马鱼上丘脑由松果体和副松果体器官以及位于松果体复合体两侧的成对缰核组成。虽然斑马鱼的松果体和副松果体器官起源于共同的细胞群体，但副松果体细胞经历了一个独立的程序，使它们能够迁移到松果体原基的左侧。研究导致斑马鱼大脑侧化的过程将有助于更好地理解人类大脑侧化是如何形成的。
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本文引用的文献
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