Gobbo Alessandra, Messina Andrea, Vallortigara Giorgio
Centre for Mind/Brain Sciences, University of Trento, Rovereto, Italy.
Front Behav Neurosci. 2025 Jan 20;19:1527572. doi: 10.3389/fnbeh.2025.1527572. eCollection 2025.
The left and right sides of the brain show anatomical, neurochemical and functional differences. In the past century, brain and behavior lateralization was considered a human peculiarity associated with language and handedness. However, nowadays lateralization is known to occur among all vertebrates, from primates to fish. Fish, especially zebrafish (), have emerged as a crucial model for exploring the evolution and mechanisms of brain asymmetry. This review summarizes recent advances in zebrafish research on brain lateralization, highlighting how genetic tools, imaging, and transgenic methods have been used to investigate left-right asymmetries and their impact on sensory, cognitive, and social behaviors including possible links to neurodevelopmental and neurodegenerative disorders.
大脑的左右两侧在解剖学、神经化学和功能上存在差异。在过去的一个世纪里，大脑和行为的侧化被认为是与语言和用手习惯相关的人类特性。然而，如今已知侧化现象在从灵长类到鱼类的所有脊椎动物中都存在。鱼类，尤其是斑马鱼，已成为探索大脑不对称性的进化和机制的关键模型。这篇综述总结了斑马鱼大脑侧化研究的最新进展，强调了基因工具、成像技术和转基因方法如何被用于研究左右不对称性及其对感觉、认知和社会行为的影响，包括与神经发育和神经退行性疾病的可能联系。
