Cipolli P L, Bo P, Marchioni E, Matti C, Savoldi F, Taccola A
Servizio Analisi Microbiologiche IRCCS Policlinico S. Matteo, Pavia.
Ital J Neurol Sci. 1991 Jun;12(3):289-93. doi: 10.1007/BF02337776.
Within the framework of a research carried out at the Neurological Institute of Pavia on experimental cerebral ischemia some biohumoral determinations were done on two groups of rabbits: one kept on a standard diet and the other on an atherogenic diet to induce dyslipemia. The aim was to find out whether induced ischemia produces an activation of the hemocoagulation processes and whether hyperdyslipemia constitutes an aggravating factor. In the animals on a standard diet there was a statistically significant increase in factor X A and a nonsignificant increase in parameter (r + k) on TEG (thromboelastogram) and of factor VIII C after embolization. In the hyperdyslipemic group the changes were definitely more marked and, in the case of factor VIII C and parameter (r + k), statistically significant, accompanied by slight variations in APTT and factor IX pointing in the same direction. We discuss the meaning of our findings.
在帕维亚神经研究所进行的一项关于实验性脑缺血的研究框架内，对两组兔子进行了一些生物体液测定：一组保持标准饮食，另一组采用致动脉粥样硬化饮食以诱发血脂异常。目的是弄清楚诱导性缺血是否会激活血液凝固过程，以及高度血脂异常是否构成一个加重因素。在标准饮食的动物中，栓塞后因子X A有统计学意义的增加，血栓弹力图（TEG）上的参数（r + k）有不显著的增加，以及因子VIII C增加。在高度血脂异常组中，变化肯定更为明显，就因子VIII C和参数（r + k）而言，具有统计学意义，同时活化部分凝血活酶时间（APTT）和因子IX有轻微变化且指向相同方向。我们讨论了我们研究结果的意义。
