Taccola A, Savoldi F, Di Maio D, Giorgetti A, Bo P
Centro per le Malattie Cardiovascolari Professionali dell'Università di Pavia.
Minerva Med. 1989 Jan;80(1):71-7.
Within the framework of an investigation at present under way at the Neurological Clinic of Pavia on experimental focal ischaemia, the peculiarities of platelet aggregation observed, have led to a more accurate assessment of both the phenomenon itself and the validity of the method used. In a group of 30 rabbits (17 of them submitted to embolization by means of microspheres introduced into the carotid and 13 used as controls), biohumoral electrical and histological parameters were examined. The spontaneous platelet aggregation test proved significantly related to the extent of changes taking place, as measured by PDS levels and QEEG "delta" activity (respectively, P less than 0.005 and P less than 0.05). Platelet aggregation, in relation to the occurrence or absence of focal ischaemia, revealed a "sensitivity" of 80% and a "specificity" of 92.3%. When not only the onset of but also the increase in aggregation is taken into account, the "sensitivity" figure appears to go up to 93.3%. Endothelial damage and "cascade" platelet aggregation appeared to be a prerequisite for the occurrence of the changes found. In these changes, the pathogenetic role of the regional vasospasm as opposed to mere mechanical obstruction seems to be confirmed. On the basis of these findings, it is concluded that the identification of spontaneous platelet aggregation using K. Breddin's method and its quantification based on Born's turbidimetric principle, may be usefully employed to assess the risk factor constituted by an abnormal tendency to platelet hyperaggregation.
在帕维亚神经科诊所目前正在进行的一项关于实验性局灶性缺血的研究框架内，所观察到的血小板聚集特性，使得对该现象本身以及所用方法的有效性有了更准确的评估。在一组30只兔子中（其中17只通过向颈动脉内注入微球进行栓塞，13只作为对照），对生物体液电学和组织学参数进行了检查。自发血小板聚集试验证明与所发生变化的程度显著相关，变化程度通过PDS水平和脑电图“δ”活动来衡量（分别为P＜0.005和P＜0.05）。与局灶性缺血的发生与否相关的血小板聚集，显示出“敏感性”为80%，“特异性”为92.3%。当不仅考虑聚集的开始而且考虑聚集的增加时，“敏感性”数字似乎上升到93.3%。内皮损伤和“级联”血小板聚集似乎是所发现变化发生的先决条件。在这些变化中，与单纯机械性阻塞相对的局部血管痉挛的致病作用似乎得到了证实。基于这些发现，可以得出结论，使用K. Breddin方法识别自发血小板聚集并基于Born比浊法原理对其进行定量，可有效地用于评估由血小板过度聚集异常倾向构成的危险因素。
