Pedroza Alvaro, Huerta José G, Garcia Maria de la Luz, Rojas Arsheli, López-Martínez Irma, Penagos Martín, Franco-Paredes Carlos, Deroche Christele, Mascareñas Cesar
Instituto Nacional de Pediatría, Secretaria de Salud México, Mexico.
Int J Infect Dis. 2009 Jul;13(4):469-75. doi: 10.1016/j.ijid.2008.08.015. Epub 2008 Dec 11.
The morbidity and mortality associated with influenza is substantial in children with asthma. There are no available data on the safety and immunogenicity of influenza vaccine in children with asthma in Latin America. Furthermore, it is unclear if influenza vaccination may cause asthma exacerbations.
We conducted a placebo-controlled trial to investigate the safety and immunogenicity of an inactivated trivalent split virus influenza vaccine in children with asthma in Mexico. We also measured the impact of influenza vaccination on pulmonary function tests in this population.
The inactivated influenza vaccine was immunogenic and safe in terms of local and systemic side effects compared to placebo. We observed no significant impact on pulmonary function tests among vaccine recipients.
Given the significant morbidity associated with influenza in children, strategies to promote increased influenza vaccination coverage in this high-risk group in Latin America and elsewhere are urgently needed.
哮喘儿童感染流感后的发病率和死亡率很高。拉丁美洲尚无关于哮喘儿童接种流感疫苗的安全性和免疫原性的可用数据。此外，尚不清楚接种流感疫苗是否会引发哮喘加重。
我们开展了一项安慰剂对照试验，以研究一种灭活三价裂解病毒流感疫苗在墨西哥哮喘儿童中的安全性和免疫原性。我们还测定了流感疫苗接种对该人群肺功能测试的影响。
与安慰剂相比，灭活流感疫苗在局部和全身副作用方面具有免疫原性且安全。我们观察到疫苗接种者的肺功能测试无显著影响。
鉴于儿童流感相关的高发病率，迫切需要采取策略提高拉丁美洲及其他地区这一高危群体的流感疫苗接种覆盖率。
