Robichaud Julie A, Pfann Kerstin D, Leurgans Sue, Vaillancourt David E, Comella Cynthia L, Corcos Daniel M
Department of Kinesiology and Nutrition (M/C 994), University of Illinois at Chicago, 1919 West Taylor Street, 650 AHSB, MC 994, Chicago, IL 60612, USA.
Clin Neurophysiol. 2009 Feb;120(2):390-7. doi: 10.1016/j.clinph.2008.10.015. Epub 2008 Dec 11.
This study evaluated whether changes in the electromygraphic (EMG) pattern during rapid point-to-point movements in individuals diagnosed with PD can: (1) distinguish PD subjects from healthy subjects and (2) determine if differences in the EMG pattern reflect disease severity in PD.
Three groups of 10 PD subjects and 10 age/sex-matched healthy subjects performed rapid 72 degree point-to-point elbow flexion movements. PD subjects were divided, a priori, into three groups based upon off medication motor UPDRS score.
Measures related to the EMG pattern distinguished all PD subjects and 9 out of 10 healthy subjects, resulting in 100% sensitivity. Further, significant correlations were shown between EMG measures and the motor UPDRS score. After 30 months, the one healthy subject whose EMG pattern was abnormal was reexamined. The EMG measures remained abnormal and the motor UPDRS score went from 0 to 10. Parkinson's disease was diagnosed.
Measures related to the variability of the EMG pattern during rapid point-to-point movements provide neurophysiological measures that objectively distinguish PD subjects from healthy subjects. These measures also correlate with disease severity.
EMG measures may provide a non-invasive measure that is sensitive and specific for identifying individuals with PD.
本研究评估了被诊断为帕金森病（PD）的个体在快速点对点运动过程中肌电图（EMG）模式的变化是否能够：（1）区分PD患者与健康受试者；（2）确定EMG模式的差异是否反映PD的疾病严重程度。
三组，每组10名PD患者和10名年龄/性别匹配的健康受试者进行了快速72度点对点肘部屈曲运动。根据停药时的运动性统一帕金森病评定量表（UPDRS）评分，将PD患者预先分为三组。
与EMG模式相关的测量区分了所有PD患者和10名健康受试者中的9名，敏感性达100%。此外，EMG测量与运动性UPDRS评分之间存在显著相关性。30个月后，对1名EMG模式异常的健康受试者进行了复查。EMG测量结果仍异常，运动性UPDRS评分从0升至10。该受试者被诊断为帕金森病。
与快速点对点运动过程中EMG模式变异性相关的测量提供了客观区分PD患者与健康受试者的神经生理学指标。这些指标也与疾病严重程度相关。
EMG测量可能提供一种对识别PD个体敏感且特异的非侵入性测量方法。
