Pfann K D, Buchman A S, Comella C L, Corcos D M
School of Kinesiology, University of Illinois at Chicago, 60608-1516, USA.
Mov Disord. 2001 Nov;16(6):1048-65. doi: 10.1002/mds.1220.
Studies of electromyographic (EMG) patterns during movements in Parkinson's disease (PD) have often yielded contradictory results, making it impossible to derive a set of rules to explain how muscles are activated to perform different movement tasks. We sought to clarify the changes in modulation of EMG parameters associated with control of movement distance during fast movements in patients with PD. Specifically, we studied surface EMG activity during rapid elbow flexion movements over a wide range of distances (5-72 degrees) in 14 patients with relatively mild symptoms of PD and 14 control subjects of similar age, sex, height, and weight. The PD group exhibited several changes in EMG modulation including impaired modulation of agonist burst duration; increased number of agonist bursts; reduced scaling of agonist EMG magnitude in the more severely impaired subjects; and increased temporal overlap of the antagonist and agonist signals in the most severely impaired subjects. These findings suggest that progressive motor dysfunction in PD is accompanied by increasing deficits in modulating muscle activation. These results help clarify previous disparate and sometimes contradictory results of EMG patterns in subjects with PD.
对帕金森病（PD）患者运动过程中肌电图（EMG）模式的研究常常得出相互矛盾的结果，因此无法得出一套规则来解释肌肉是如何被激活以执行不同的运动任务。我们试图阐明PD患者快速运动过程中与运动距离控制相关的EMG参数调制变化。具体而言，我们研究了14例症状相对较轻的PD患者和14例年龄、性别、身高和体重相似的对照受试者在5-72度的广泛距离范围内快速屈肘运动时的表面EMG活动。PD组在EMG调制方面表现出多种变化，包括激动剂爆发持续时间调制受损；激动剂爆发次数增加；在受损更严重的受试者中，激动剂EMG幅度缩放减小；在受损最严重的受试者中，拮抗剂和激动剂信号的时间重叠增加。这些发现表明，PD患者进行性运动功能障碍伴随着调节肌肉激活的缺陷增加。这些结果有助于澄清先前在PD患者中EMG模式的不同且有时相互矛盾的结果。
