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巨大芬戈尔德菌,感染性心内膜炎术后早期病因:两例报告并文献复习

Finegoldia magna, an early post-operative cause of infectious endocarditis: report of two cases and review of the literature.

作者信息

Fournier Pierre-Edouard, La My Van, Casalta Jean-Paul, Richet Hervé, Collart Frédéric, Raoult Didier

机构信息

Fédération de Microbiologie, Hôpital de la Timone, Marseille Hôpital de la Timone, rue Saint Pierre, 13385 Marseille Cedex 5, France.

出版信息

Anaerobe. 2008 Dec;14(6):310-2. doi: 10.1016/j.anaerobe.2008.11.001. Epub 2008 Dec 3.

Abstract

We report two cases of infectious endocarditis (IE) on prosthetic valves caused by Finegoldia magna. The diagnosis was obtained by detection of the bacterium in valvular biopsies using 16S rRNA PCR amplication and sequencing, and prolonged culture. Five other cases were previously published in the literature. Following analysis of these seven cases, F. magna endocarditis presented as a subacute endocarditis, developing early (60 days) following valvular replacement (85%), with an elevated mortality (28%). Our report highlights the potential role of F. magna in early post-surgical endocarditis on prosthetic valves.

摘要

我们报告了两例由巨大芬戈尔德菌引起的人工瓣膜感染性心内膜炎(IE)病例。通过使用16S rRNA PCR扩增和测序以及延长培养时间在瓣膜活检中检测到该细菌而确诊。此前文献中还发表过另外五例病例。对这七例病例进行分析后发现,巨大芬戈尔德菌心内膜炎表现为亚急性心内膜炎,在瓣膜置换术后早期(60天)发病(85%),死亡率较高(28%)。我们的报告强调了巨大芬戈尔德菌在人工瓣膜术后早期心内膜炎中的潜在作用。

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