Warwick Orthopaedics, Clinical Sciences Research Institute, University Hospital Coventry and Warwickshire, Department of Trauma and Orthopaedics, Clifford Bridge Road, Coventry CV2 2DX, UK.
Injury. 2009 Feb;40(2):158-62. doi: 10.1016/j.injury.2008.06.025. Epub 2008 Dec 12.
Platelet-rich plasma has been shown in several in vitro and animal studies to play a role in promoting new bone formation. A systematic literature review was conducted to identify the current relevant evidence base, searching across multiple sources including Medline, Embase and the Cochrane Library, and finding five clinically relevant articles. Only one was a randomised controlled trial, but this was underpowered for the outcome measure defined. Three studies exclusively concerned children, and included those with congenital limb deformities. Two other reports were case series. Early clinical results suggest that the use of platelet-rich plasma is safe and feasible, but that at present there is no clinical evidence of benefit in either acute or delayed fracture healing.
富血小板血浆已在多项体外和动物研究中显示出在促进新骨形成中发挥作用。进行了系统的文献回顾，以确定当前相关的证据基础，搜索了多个来源，包括 Medline、Embase 和 Cochrane 图书馆，并找到了五篇具有临床相关性的文章。只有一篇是随机对照试验，但对于所定义的结果测量，该试验的效力不足。三项研究专门针对儿童，包括先天性肢体畸形患者。另外两项报告是病例系列。早期临床结果表明，使用富血小板血浆是安全且可行的，但目前在急性或延迟骨折愈合方面均没有临床获益的证据。
