β地中海贫血/血红蛋白E病合并妊娠的结局
Outcomes of pregnancies complicated by beta-thalassemia/hemoglobin E disease.
作者信息
Luewan Suchaya, Srisupundit Kasemsri, Tongsong Theera
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
出版信息
Int J Gynaecol Obstet. 2009 Mar;104(3):203-5. doi: 10.1016/j.ijgo.2008.10.012. Epub 2008 Dec 12.
OBJECTIVE
To assess the outcomes of pregnancies affected by beta-thalassemia/hemoglobin E (beta-thal/HbE) disease.
METHODS
A retrospective cohort study was conducted with 54 women with singleton pregnancies complicated by beta-thal/HbE disease only. The controls-to-cases ratio was 2:1.
RESULTS
Although maternal outcomes were similar in both groups, gestational age at birth and birth weight were significantly lower in the study group and the cesarean delivery rate was significantly higher in that group (relative risk [RR], 2.1). The incidences of fetal growth restriction, preterm birth, and low birth weight were also significantly higher in the study group, with RRs of 2.8, 2.7, and 5.6, respectively.
CONCLUSION
Pregnancies affected by beta-thal/HbE disease were significantly associated with an increased risk of fetal growth restriction, preterm birth, and low birth weight.
目的
评估受β地中海贫血/血红蛋白E（β-地贫/HbE）疾病影响的妊娠结局。
方法
进行了一项回顾性队列研究，纳入54名单胎妊娠且仅合并β-地贫/HbE疾病的女性。对照与病例的比例为2:1。
结果
尽管两组的母亲结局相似，但研究组的出生孕周和出生体重显著更低，且该组的剖宫产率显著更高（相对风险[RR]，2.1）。研究组胎儿生长受限、早产和低出生体重的发生率也显著更高，RR分别为2.8、2.7和5.6。
结论
受β-地贫/HbE疾病影响的妊娠与胎儿生长受限、早产和低出生体重风险增加显著相关。
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