Yordanova D, Nikolov A, Museva A, Karamiseva V
Akush Ginekol (Sofiia). 2014;53 Suppl 1:20-4.
Thalassemia syndromes are heterogenic group hereditary hemoglobinopathies, provoking chronic hemolytic anemia. They affect approximately 100 million people, mostly in the Mediterranean (including Bulgaria), South-eastern Asia and Africa. Thalassemia syndromes are the second reason for hypochromic anemia and anemia in pregnancy after iron deficiency.
To determine pregnancy outcome of women with β-thalassemia minor.
It is an ambispective study in University Hospital of Obstetrics and Gynecology" Maichin dom", Sofia, for a year. Patients are divided in two groups regarding the presence of β-thalassemia minor. Preeclampsia, gestational diabetes mellitus, olygo- and polyhydramnion, preterm labor intrauterine growth retardation (IUGR), Cesarean section delivery are recorded in study groups.
Cases with β-thalassemia minor have significantly higher prevalence of oligohydramnion and Cesarean section delivery. There is no significant difference regarding Apgar score in 1st and 5th minute, IUGR, gestational diabetes mellitus and preeclampsia between two study groups.
β-Thalassemia minor does not significantly influence the pregnancy in negative way.
地中海贫血综合征是一组遗传性血红蛋白病，可引发慢性溶血性贫血。该病影响约1亿人，主要分布在地中海地区（包括保加利亚）、东南亚和非洲。地中海贫血综合征是缺铁后导致低色素性贫血和孕期贫血的第二大原因。
确定轻型β地中海贫血女性的妊娠结局。
这是在索非亚“麦钦多姆”妇产科大学医院进行的一项为期一年的前瞻性研究。根据是否存在轻型β地中海贫血将患者分为两组。记录研究组中的子痫前期、妊娠期糖尿病、羊水过少和羊水过多、早产、胎儿宫内生长受限（IUGR）、剖宫产分娩情况。
轻型β地中海贫血病例中羊水过少和剖宫产分娩的发生率显著更高。两个研究组在第1分钟和第5分钟的阿氏评分、胎儿宫内生长受限、妊娠期糖尿病和子痫前期方面无显著差异。
轻型β地中海贫血不会对妊娠产生显著负面影响。
