Kounis Geoge-N, Kouni Sophia-A, Hahalis George, Kounis Nicholas-G
Department of Medical Sciences, Patras Highest Institute of Education and Technology, Queel Olgas Square Patras 26221, Greece.
World J Gastroenterol. 2008 Dec 14;14(46):7141-2. doi: 10.3748/wjg.14.7141.
5-aminosalicylic acid (mesalamine) rarely induces hypersensitivity reactions. If chest pain associated with atypical electrocardiographic changes are seen during its administration, one should always bear in mind type I variant of Kounis syndrome. This variant includes patients, of any age, with normal coronary arteries, without predisposing factors for coronary artery disease, in whom the acute release of inflammatory mediators from mast cells can induce either sudden coronary artery narrowing, without increase of cardiac enzymes and troponins, or coronary artery spasm that progresses to acute myocardial infarction, with elevated cardiac enzymes and troponins.
5-氨基水杨酸（美沙拉嗪）很少引起过敏反应。如果在用药期间出现伴有非典型心电图改变的胸痛，应始终牢记库尼斯综合征I型变异。该变异包括任何年龄、冠状动脉正常、无冠状动脉疾病易感因素的患者，其中肥大细胞炎性介质的急性释放可导致冠状动脉突然狭窄（心肌酶和肌钙蛋白不升高），或冠状动脉痉挛进而发展为急性心肌梗死（心肌酶和肌钙蛋白升高）。
