Adachi E, Okazaki K, Matsushima Y, Seno H, Uchida K, Nakase H, Kawanami C, Nakamura T, Chiba T
Department of Gastroenterology and Hepatology, and Endoscopic Medicine, Kyoto University Hospital, Japan.
Int J Pancreatol. 1999 Jun;25(3):217-21. doi: 10.1007/BF02925970.
Therapy with oral 5-aminosalicylic acid (5-ASA) for ulcerative colitis has been reported to be effective and safe. We describe a case of biochemically proven mild acute pancreatitis occurring after 9 d of oral 5-ASA therapy for ulcerative colitis. A hypersensitivity mechanism seemed to be involved in the development of pancreatitis probably owing to erratic systemic absorption of the drug. We suggest clinical and biochemical monitoring for early diagnosis of pancreatitis in patients with ulcerative colitis receiving 5-ASA administration. This is the first report of acute pancreatitis developed by oral 5-ASA therapy for the treatment of ulcerative colitis in the literature of Japan.
据报道，口服5-氨基水杨酸（5-ASA）治疗溃疡性结肠炎有效且安全。我们描述了1例在口服5-ASA治疗溃疡性结肠炎9天后发生的经生化证实的轻度急性胰腺炎病例。胰腺炎的发生可能与药物全身吸收不稳定有关，似乎涉及超敏反应机制。我们建议对接受5-ASA治疗的溃疡性结肠炎患者进行临床和生化监测，以便早期诊断胰腺炎。这是日本文献中关于口服5-ASA治疗溃疡性结肠炎引发急性胰腺炎的首例报告。
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