Ikuta Shin-ichi, Aihara Tsukasa, Yasui Chiaki, Iida Hiroya, Yanagi Hidenori, Mitsunobu Masao, Kakuno Ayako, Yamanaka Naoki
Department of Surgery, Meiwa General Hospital, Agenaruo 4-31, Nishinomiya, Hyogo 663-8186, Japan.
World J Gastroenterol. 2008 Dec 21;14(47):7252-5. doi: 10.3748/wjg.14.7252.
Mucinous cystic neoplasms (MCNs) of the pancreas occur mostly in females and are potentially sex hormone-sensitive. However, a MCN occurring during pregnancy is quite rare. A 30-year-old woman in the tenth week of pregnancy was referred to us because of a rapid increase in left hypochondrial distending pain. On ultrasound, the patient had a large intra-abdominal cystic lesion. She was thereafter diagnosed with missed abortion and a computed tomography scan showed that the lesion was a cystic tumor 18 cm in diameter originating from the pancreatic tail. The patient subsequently underwent tumor resection with distal pancreatectomy, sparing the spleen. Histopathological analysis of the specimen revealed a pancreatic MCN with moderate dysplasia. Immunohistochemically, the tumor was positive for both estrogen and progesterone receptors. To our knowledge, this is the first reported case of pancreatic MCN with moderate dysplasia in association with pregnancy. Our case strongly indicates that pancreatic MCN is female-hormone dependent.
胰腺黏液性囊性肿瘤（MCNs）大多发生于女性，可能对性激素敏感。然而，孕期发生的MCN相当罕见。一名怀孕10周的30岁女性因左季肋部胀痛迅速加剧被转诊至我院。超声检查显示，该患者有一个巨大的腹腔内囊性病变。随后她被诊断为稽留流产，计算机断层扫描显示该病变是一个直径18厘米、起源于胰尾的囊性肿瘤。患者随后接受了肿瘤切除及远端胰腺切除术，保留了脾脏。标本的组织病理学分析显示为伴有中度发育异常的胰腺MCN。免疫组化显示，该肿瘤的雌激素和孕激素受体均为阳性。据我们所知，这是首例报道的伴有中度发育异常且与妊娠相关的胰腺MCN病例。我们的病例有力地表明胰腺MCN依赖女性激素。
