Youssef M M, Abu Samra L M, Hegazy I H
Department of Parasitology, Faculty of Medicine, Alexandroa University, Egypt.
J Egypt Soc Parasitol. 1991 Aug;21(2):309-18.
The antigenic fraction of a cell free homogenate of each of Trichinella spiralis and T. pseudospiralis were prepared to be used for induction of immunity against S. mansoni in albino mice. The results of the study showed that immunization with either of the two antigens induced reduction in worm load ranging from 80.48% to 87.86% in the different groups of the study. Reduction in tissue egg count was also reported: Liver egg count was reduced from 69.47% to 100%. Intestinal egg count reduction ranged from 73.83% to 99.78%. There was also reduction in egg excretion as evidenced by diminution in stool egg count. Liver granulomas were less in number and size and showed accelerated reaction together with inhibition of fluorescence. These findings were more manifest in animals given T. spiralis than T. pseudospiralis antigen.
制备旋毛虫和伪旋毛虫的无细胞匀浆的抗原部分，用于诱导白化小鼠对曼氏血吸虫的免疫力。研究结果表明，用两种抗原中的任何一种进行免疫，在研究的不同组中，虫负荷减少了80.48%至87.86%。还报告了组织虫卵计数的减少：肝脏虫卵计数从69.47%降至100%。肠道虫卵计数减少范围为73.83%至99.78%。粪便虫卵计数减少证明虫卵排泄也减少了。肝脏肉芽肿的数量和大小较少，显示出加速反应以及荧光抑制。这些发现在用旋毛虫抗原的动物中比用伪旋毛虫抗原的动物中更明显。
