Kaneko K, Shiraishi K, Nishizawa H, Furuya R, Yamaguchi O, Usuda Y, Okutsu Y, Okumura F
Department of Anesthesiology, Yokohama City University School of Medicine.
Masui. 1991 Jun;40(6):956-9.
The effects of end-expiratory negative extra-thoracic pressure (EENETP) and PEEP on the ventilatory response to CO2 were studied in seven healthy volunteers. The changes in functional residual capacity during EENETP -20 cmH2O and PEEP 5 cmH2O were 13.9 and 12.9 ml.kg-1, respectively. The slopes of CO2 response (minute ventilation/end-tidal CO2) during ZEEP, EENETP and PEEP were 0.913, 0.622, 0.693 l.min-1.mmHg-1, respectively. The slopes during EENETP and PEEP were significantly decreased. These results indicate that EENETP and PEEP could worsen the CO2 response in patients with respiratory failure, especially, with chronic obstructive pulmonary disease in which functional residual capacity is increased.
在七名健康志愿者中研究了呼气末胸外负压（EENETP）和呼气末正压（PEEP）对二氧化碳通气反应的影响。EENETP为-20 cmH₂O和PEEP为5 cmH₂O时，功能残气量的变化分别为13.9和12.9 ml·kg⁻¹。零呼气末正压（ZEEP）、EENETP和PEEP期间二氧化碳反应的斜率（分钟通气量/呼气末二氧化碳分压）分别为0.913、0.622、0.693 l·min⁻¹·mmHg⁻¹。EENETP和PEEP期间的斜率显著降低。这些结果表明，EENETP和PEEP可能会使呼吸衰竭患者，尤其是功能残气量增加的慢性阻塞性肺疾病患者的二氧化碳反应恶化。
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