帕金森病中脑桥脚核的深部脑刺激。牛津大学的初步经验。
Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford.
作者信息
Pereira E A, Muthusamy K A, De Pennington N, Joint C A, Aziz T Z
机构信息
Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK.
出版信息
Br J Neurosurg. 2008;22 Suppl 1:S41-4. doi: 10.1080/02688690802448335.
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.
对脚桥核（PPN）进行深部脑刺激（DBS）是一种新型神经外科治疗方法，旨在解决帕金森病及相关疾病中的步态冻结和姿势不稳症状。在此，我们总结了与我们对PPN的手术靶点相关的非人灵长类动物和神经影像学研究。我们还描述了PPN DBS的临床经验，低频刺激可实现最大程度的运动改善。
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