Baas Jorgen, Elmengaard Brian, Bechtold Joan, Chen Xinqian, Søballe Kjeld
Orthopedic Research Laboratory, Aarhus University Hospital, Denmark.
Acta Orthop. 2008 Dec;79(6):841-50. doi: 10.1080/17453670810016948.
We studied whether osseointegration and fixation of plasma-sprayed titanium implants grafted with beta-TCP granules (Ossaplast) can be improved by adding an osteogenic signal (Colloss E). The results were compared to implants grafted with fresh frozen morselized allograft with and without the Colloss E device.
4 porous-coated Ti implants were placed in the proximal humeri in each of 10 dogs. All implants were surrounded by a 2.5-mm defect, which was grafted with: (A) beta-TCP, (B) beta-TCP+20 mg Colloss E, (C) allograft, or (D) allograft+20 mg Colloss E. The observation time was 4 weeks.
Mechanical testing showed that the beta-TCP group with Colloss E was twice as well fixed as the control group grafted with beta-TCP granules alone, and comparable to both allograft groups. We found that every control implant in the beta-TCP grafted group was covered by a dense fibrous membrane. No fibrous tissue was seen in the beta-TCP group augmented with Colloss. These implants were well osseointegrated, with new bone covering 10-25% of the implant surface. Both treated groups had increased graft resorption compared to their respective control groups. Colloss E had no effect on new bone formation or fibrous tissue reduction around the allografted implants.
The Colloss E device improved early osseointegration of implants grafted with beta-TCP granules and increased their mechanical implant fixation to the level of allografted implants. The experiment indicates that ceramic bone substitutes may be a viable alternative to allograft when combined with an osteogenic signal such as Colloss E.
我们研究了添加成骨信号（Colloss E）是否能改善移植了β - 磷酸三钙颗粒（Ossaplast）的等离子喷涂钛植入物的骨整合及固定情况。将结果与移植了新鲜冷冻碎异体骨且有或没有Colloss E装置的植入物进行比较。
在10只犬的每只犬的近端肱骨中植入4个多孔涂层钛植入物。所有植入物周围均有一个2.5毫米的缺损，缺损处移植有：（A）β - 磷酸三钙，（B）β - 磷酸三钙 + 20毫克Colloss E，（C）异体骨，或（D）异体骨 + 20毫克Colloss E。观察时间为4周。
力学测试表明，添加Colloss E的β - 磷酸三钙组的固定效果是单独移植β - 磷酸三钙颗粒的对照组的两倍，且与两个异体骨组相当。我们发现，β - 磷酸三钙移植组中的每个对照植入物都被一层致密的纤维膜覆盖。添加Colloss的β - 磷酸三钙组未见纤维组织。这些植入物骨整合良好，新骨覆盖植入物表面的10% - 25%。与各自的对照组相比，两个治疗组的移植物吸收均增加。Colloss E对异体骨移植植入物周围的新骨形成或纤维组织减少没有影响。
Colloss E装置改善了移植β - 磷酸三钙颗粒的植入物的早期骨整合，并将其机械植入固定提高到异体骨移植植入物的水平。该实验表明，陶瓷骨替代物与成骨信号如Colloss E联合使用时，可能是异体骨移植的可行替代方案。
