腹膜透析患者静脉注射达托霉素的药代动力学及透析液水平
Pharmacokinetics and dialysate levels of daptomycin given intravenously in a peritoneal dialysis patient.
作者信息
Goedecke Vega A, Clajus Christian, Burkhardt Olaf, Martens-Lobenhoffer Jens, Bode-Boger Stefanie M, Kielstein Jan T, Hiss Marcus
机构信息
Department of Internal Medicine, Division of Nephrology and Hypertension.
出版信息
Scand J Infect Dis. 2009;41(2):155-7. doi: 10.1080/00365540802613095.
In this report we present pharmacokinetic (Pk) data of daptomycin given intravenously in a peritoneal dialysis patient. Daptomycin plasma levels were within therapeutic range; however, half-life of the drug was prolonged compared to haemodialysis. Both plasma and dialysate levels were found to be consistently above the minimal inhibitory concentration for daptomycin sensitive strains.
在本报告中，我们呈现了在一名腹膜透析患者中静脉注射达托霉素的药代动力学（Pk）数据。达托霉素的血浆水平在治疗范围内；然而，与血液透析相比，该药物的半衰期延长。血浆和透析液水平均持续高于对达托霉素敏感菌株的最低抑菌浓度。
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