Ramdas Sagar, Yousaf Farzana, Shastri Madhur D, Wanandy Troy, Zaidi Syed T R, Khandagale Manish, Jose Matthew, Patel Rahul P
Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Pharmacy Department, Royal Hobart Hospital, Hobart, Tasmania, Australia.
Eur J Hosp Pharm. 2016 Jan;23(1):57-60. doi: 10.1136/ejhpharm-2015-000651. Epub 2015 Aug 20.
Intraperitoneal daptomycin is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by vancomycin-resistant bacteria. This study investigated the stability of daptomycin in a pH-neutral PD solution.
Reconstituted solution of daptomycin was added to a total of nine PD bags to obtain a concentration of 20 mg/L and stored at 1 of 3 different temperatures: 4 or 25°C for up to 168 h or 37°C for up to 48 h. Stabilities were determined by visual inspection, pH measurement and high-performance liquid chromatography.
Daptomycin retained more than 90% of its initial concentration for 120, 72 and 12 h at 4°C, 25°C and 37°C, respectively. No physical precipitation or pH change was observed during the study.
Daptomycin in a pH-neutral PD solution is physically and chemically stable for 120 and 12 h at 4°C and 37°C, respectively.
腹腔内使用达托霉素用于治疗由耐万古霉素细菌引起的腹膜透析（PD）相关腹膜炎。本研究调查了达托霉素在pH值中性的腹膜透析液中的稳定性。
将达托霉素复溶溶液加入总共9个腹膜透析袋中，使其浓度达到20mg/L，并在3个不同温度之一储存：4℃或25℃下储存168小时，或37℃下储存48小时。通过目视检查、pH测量和高效液相色谱法测定稳定性。
达托霉素在4℃、25℃和37℃下分别在120小时、72小时和12小时内保持其初始浓度的90%以上。研究期间未观察到物理沉淀或pH值变化。
pH值中性的腹膜透析液中的达托霉素在4℃和37℃下分别在物理和化学上稳定120小时和12小时。
