重症肌无力与视神经脊髓炎中神经自身免疫血清学标志物的共存。
Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica.
作者信息
McKeon Andrew, Lennon Vanda A, Jacob Anu, Matiello Marcelo, Lucchinetti Claudia F, Kale Nilufer, Chan Koon H, Weinshenker Brian G, Apiwattinakul Metha, Wingerchuk Dean M, Pittock Sean J
机构信息
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
出版信息
Muscle Nerve. 2009 Jan;39(1):87-90. doi: 10.1002/mus.21197.
We systematically evaluated the frequency of neurological disorders and muscle and neural autoantibodies in 177 patients with neuromyelitis optica (NMO) and in 250 control subjects (173 healthy; 77 multiple sclerosis, MS, patients). An excess of myasthenia gravis (MG, 2%), and muscle-type acetylcholine receptor antibody (11%) was detected among NMO patients. The presence of neural or muscle autoantibodies was more common in NMO patients (34%) than in MS patients or healthy controls (7%), P < 0.0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder.
我们系统评估了177例视神经脊髓炎（NMO）患者以及250名对照受试者（173名健康者；77例多发性硬化症，MS，患者）的神经系统疾病、肌肉及神经自身抗体的出现频率。在NMO患者中检测到重症肌无力（MG，2%）及肌肉型乙酰胆碱受体抗体（11%）比例过高。NMO患者中神经或肌肉自身抗体的存在（34%）比MS患者或健康对照（7%）更为常见，P<0.0001。在任何一种疾病的非典型或难治性表现中，都应考虑NMO与MG共存的情况。
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