McKeon Andrew, Lennon Vanda A, Jacob Anu, Matiello Marcelo, Lucchinetti Claudia F, Kale Nilufer, Chan Koon H, Weinshenker Brian G, Apiwattinakul Metha, Wingerchuk Dean M, Pittock Sean J
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Muscle Nerve. 2009 Jan;39(1):87-90. doi: 10.1002/mus.21197.
We systematically evaluated the frequency of neurological disorders and muscle and neural autoantibodies in 177 patients with neuromyelitis optica (NMO) and in 250 control subjects (173 healthy; 77 multiple sclerosis, MS, patients). An excess of myasthenia gravis (MG, 2%), and muscle-type acetylcholine receptor antibody (11%) was detected among NMO patients. The presence of neural or muscle autoantibodies was more common in NMO patients (34%) than in MS patients or healthy controls (7%), P < 0.0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder.
我们系统评估了177例视神经脊髓炎（NMO）患者以及250名对照受试者（173名健康者；77例多发性硬化症，MS，患者）的神经系统疾病、肌肉及神经自身抗体的出现频率。在NMO患者中检测到重症肌无力（MG，2%）及肌肉型乙酰胆碱受体抗体（11%）比例过高。NMO患者中神经或肌肉自身抗体的存在（34%）比MS患者或健康对照（7%）更为常见，P<0.0001。在任何一种疾病的非典型或难治性表现中，都应考虑NMO与MG共存的情况。
