Ohigashi H, Ishikawa O, Masutani S, Sasaki Y, Hiratsuka M, Kameyama M, Kabuto T, Fukuda I, Furukawa H, Imaoka S
Dept. of Surgery, Center for Adult Diseases, Osaka.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1776-9.
This study seeks to evaluate arterial infusion chemotherapy and radiotherapy for non-resectable pancreatic cancer with liver metastases. Arterial infusion to the liver was performed in 24 patients, 15 of whom received arterial infusion to the pancreas and 9 of whom underwent irradiation for pancreas tumor (40-50 Gy). However, arterial infusion to the liver alone did not prolong survival, but loco-lesional therapy for the pancreas tumor improved quality of life and resulted in good local control. The survival of the two treatment groups (arterial infusion to the liver combined with loco-regional treatment to the pancreas versus systemic chemotherapy) was statistically different (median 7 months versus 3 months, p less than 0.01). Arterial infusion to the pancreas decreased liver metastases as the first site of failure. These results suggested that arterial infusion to both liver and pancreas combined with irradiation for the pancreas tumor are effective in increasing survival time and improving the quality of life.
本研究旨在评估动脉灌注化疗和放疗对伴有肝转移的不可切除胰腺癌的疗效。对24例患者进行了肝脏动脉灌注，其中15例接受了胰腺动脉灌注，9例接受了胰腺肿瘤放疗（40-50 Gy）。然而，单纯肝脏动脉灌注并不能延长生存期，但对胰腺肿瘤的局部治疗改善了生活质量并实现了良好的局部控制。两个治疗组（肝脏动脉灌注联合胰腺局部区域治疗与全身化疗）的生存期在统计学上存在差异（中位数分别为7个月和3个月，p<0.01）。胰腺动脉灌注减少了作为首要失败部位的肝转移。这些结果表明，肝脏和胰腺动脉灌注联合胰腺肿瘤放疗可有效延长生存时间并改善生活质量。
