Ohigashi H, Ishikawa O, Nakamori S, Masutani S, Sasaki Y, Kameyama M, Hiratsuka M, Kabuto T, Furukawa H, Imaoka S
Dept. of Surgery, Center for Adult Diseases, Osaka.
Gan To Kagaku Ryoho. 1992 Aug;19(10 Suppl):1682-4.
This is a retrospective study to evaluate arterial infusion chemotherapy and radiotherapy for non-resectable pancreatic cancer without liver metastasis. Intra-arterial chemotherapy of the pancreas was performed for 17 patients, and 5 additionally received irradiation therapy. Five patients received radiation therapy alone. Both pain relief and tumor-reduction were more successful compared to the systemic chemotherapy group. In the locoregional treatment group, the patient survival rate was 50% at 1 year and 16% at 2 years. These rates were significantly higher than in the systemic chemotherapy group (p less than 0.01). Among the locoregional treatment groups, the median survival period was 7 months in radiation alone, 12 months in intra-arterial chemotherapy group, and 11 months in intra-arterial chemotherapy plus radiation group. These results suggested that locoregional treatment for pancreatic tumor is effective in increasing survival period and improving the quality of life.
这是一项回顾性研究，旨在评估动脉灌注化疗和放疗对无肝转移的不可切除胰腺癌的疗效。对17例患者进行了胰腺动脉内化疗，其中5例还接受了放射治疗。5例患者仅接受放射治疗。与全身化疗组相比，疼痛缓解和肿瘤缩小更为成功。在局部区域治疗组中，1年生存率为50%，2年生存率为16%。这些比率显著高于全身化疗组（p<0.01）。在局部区域治疗组中，单纯放疗组的中位生存期为7个月，动脉内化疗组为12个月，动脉内化疗加放疗组为11个月。这些结果表明，胰腺肿瘤的局部区域治疗在延长生存期和改善生活质量方面是有效的。
