Kameyama M, Fukuda I, Imaoka S, Masutani S, Ohigashi H, Sasaki Y, Kabuto T, Ishikawa O, Furukawa H, Koyama H
Dept. of Surgery, Center for Adult diseases, Osaka.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1808-11.
Peritoneal lavage cytology during surgery was done in 287 patients with colorectal cancer. Positive cytologic specimens were obtained from 21 patients. Of 13 patients who had free cancer cells in peritoneal cavity but no peritoneal dissemination macroscopically, 5 patients received intraperitoneal administration of 20 mg of MMC dissolved in 500 ml of saline. Peritoneal dissemination occurred in 0/5 (0%) of the MMC treated group and in 5/8 (63%) of the untreated group (p less than 0.05). Our results indicate that intraperitoneal administration of MMC (20 mg) is an effective method of preventing peritoneal dissemination after resection of colorectal cancer.
对287例结直肠癌患者在手术期间进行了腹腔灌洗细胞学检查。21例患者获得了阳性细胞学标本。在13例腹腔内有游离癌细胞但肉眼未见腹膜播散的患者中，5例患者接受了腹腔内注射溶解于500ml盐水中的20mg丝裂霉素。丝裂霉素治疗组的腹膜播散发生率为0/5（0%），未治疗组为5/8（63%）（P<0.05）。我们的结果表明，腹腔内注射丝裂霉素（20mg）是预防结直肠癌切除术后腹膜播散的有效方法。
