Jalili Shabnam, Farshid Amir Abbas, Heydari Reza, Ilkhanipour Minoo, Salehi Shahpar
Department of Biology, Faculty of Science, Urmia University, Iran.
Pak J Biol Sci. 2007 Jun 1;10(11):1922-5. doi: 10.3923/pjbs.2007.1922.1925.
The protective effects of vitamin E was investigated on the cardiotoxicity induced by endosulfan administration. Male rats in different groups were given endosulfan (2 mg per kg body weight per day in corn oil through gavage), vitamin E (200 mg per kg body weight twice a week in corn oil through gavage) and endosulfan and vitamin E at the same dose and route, to the control group corn oil is given at the dose rate of 2 mL per rat per day through gavage, for a period of28 days. The animals were sacrificed and heart tissues were collected and subjected to histopathology. The result indicated, sever congestion, haemorrhages with interstitial oedema. In some places there was diapedesis of leukocytes. Myocardium showed different degrees of degeneration, some of the myofibrils were found to be granular with pyknotic nuclei. Thickening of wall of arteries were seen. In the Vitamin E and endosulfan treated group the above mentioned lesions were significantly decreased in their severity. This study brought to light the protective effects of vitamin E on the toxic pathological lesions caused by endosulfan administration.
研究了维生素E对硫丹给药所致心脏毒性的保护作用。不同组的雄性大鼠分别给予硫丹（通过灌胃给予玉米油中每天2mg/kg体重）、维生素E（通过灌胃给予玉米油中每周两次200mg/kg体重）以及相同剂量和途径的硫丹与维生素E，对照组通过灌胃以每天每只大鼠2mL的剂量给予玉米油，持续28天。处死动物后收集心脏组织并进行组织病理学检查。结果显示，有严重充血、伴有间质水肿的出血。在一些部位有白细胞渗出。心肌呈现不同程度的变性，一些肌原纤维呈颗粒状且细胞核固缩。可见动脉壁增厚。在维生素E和硫丹处理组中，上述病变的严重程度显著降低。本研究揭示了维生素E对硫丹给药所致毒性病理损伤的保护作用。
