Kanai T, Monden M, Gotoh M, Sakon M, Kobayashi K, Umeshita K, Ukei T, Shimano T, Monden T, Morimoto H
Second Dept. of Surgery, Osaka University Medical School.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1982-6.
The efficacy of intra-arterial infusion chemotherapy for the treatment of liver metastasis was investigated in 28 colorectal cancer patients, 3 gastric cancer patients and 5 breast cancer patients between April 1986 and May 1991. 1. The long-term intra-arterial infusion chemotherapy was a simple and safe method in cancer patients. 2. We examined the serial serum CEA level in cancer patients and found that the serial change in CEA level correlated well with response to chemotherapy. The efficacy of this treatment was approximately 60% in colorectal cancer, 30% in gastric cancer, 80% in breast cancer. Intra-arterial infusion chemotherapy may be an effective treatment for the patients with liver metastasis from colorectal cancers and breast cancers. 3. In 8 colorectal cancer patients, the serum CEA level decrease to half of the pretreatment level. However, in all cases it increased significantly within 6 months postoperatively. Almost the same trend was observed in two cases of breast cancer. Our results suggest that we should give careful consideration to the resistance to anti-cancer drugs and develop a new protocol in order to obtain further satisfactory results.
1986年4月至1991年5月期间，对28例结直肠癌患者、3例胃癌患者和5例乳腺癌患者进行了肝转移动脉内灌注化疗疗效的研究。1. 长期动脉内灌注化疗对癌症患者来说是一种简单且安全的方法。2. 我们检测了癌症患者血清CEA水平的系列变化，发现CEA水平的系列变化与化疗反应密切相关。该治疗方法对结直肠癌的疗效约为60%，对胃癌为30%，对乳腺癌为80%。动脉内灌注化疗可能是治疗结直肠癌和乳腺癌肝转移患者的有效方法。3. 8例结直肠癌患者血清CEA水平降至治疗前水平的一半。然而，所有病例在术后6个月内均显著升高。2例乳腺癌患者也观察到几乎相同的趋势。我们的结果表明，我们应仔细考虑抗癌药物的耐药性，并制定新方案以获得更满意的结果。
