基于化学成分变化的当归保质期预测

[Forecast on shelf life of Chinese Angelica based on its chemical components variation].

作者信息

Xie Jing-jing, Zhao Jing, Li Shao-ping

机构信息

Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(16):1997-2001.

PMID:19086638

Abstract

OBJECTIVE

To predict the shelf life of Chinese Angelica by investigating the stability of its active components.

METHOD

The classic homeothermia method was used for forecast the shelf life, and HPLC was applied for quantitative determination of chemical compounds in Chinese Angelica.

RESULT

The correlation equations, thermal constant at ambient temperature (k(25 degrees C)) and shelf life (t(0.9)) for coniferyl ferulate and Z-Ligustilide were lgk = -5152. 1/T + 13.8 (r = 0.9985), 3. 33 x 10(-4), 13 d and lgk = -4064.6/T + 10.4 (r = 0.9997), 5.91 x 10(-4), 7 d, respectively.

CONCLUSION

The shelf life of Chinese Angelica has been established, which suggests that it is very important for ensuring the safety and efficacy of Chinese crude drug.

摘要

目的

通过研究当归有效成分的稳定性来预测其保质期。

方法

采用经典恒温法预测保质期，并用高效液相色谱法对当归中的化学成分进行定量测定。

结果

阿魏酸松柏酯和Z-藁本内酯的相关方程、常温下的热常数（k(25℃)）和保质期（t(0.9)）分别为lgk = -5152. 1/T + 13.8（r = 0.9985），3. 33 x 10(-4)，13天和lgk = -4064.6/T + 10.4（r = 0.9997），5.91 x 10(-4)，7天。