Gold Carl A, Budson Andrew E
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Expert Rev Neurother. 2008 Dec;8(12):1879-91. doi: 10.1586/14737175.8.12.1879.
Alzheimer's disease (AD) is a progressive neurodegenerative disease marked by a constellation of cognitive disturbances, the earliest and most prominent being impaired episodic memory. Episodic memory refers to the memory system that allows an individual to consciously retrieve a previously experienced item or episode of life. Many recent studies have focused on characterizing how AD pathology impacts particular aspects of episodic memory and underlying mental and neural processes. This review summarizes the findings of those studies and discusses the effects of current and promising treatments for AD on episodic memory. The goal of this review is to raise awareness of the strides that cognitive neuroscientists have made in understanding intact and dysfunctional memory. Knowledge of the specific memorial processes that are impaired in AD may be of great value to basic scientists developing novel therapies and to clinical researchers assessing the efficacy of those therapies.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其特征是一系列认知障碍，最早且最突出的是情景记忆受损。情景记忆是指允许个体有意识地回忆以前经历过的生活中的某个项目或事件的记忆系统。最近的许多研究都集中在描述AD病理学如何影响情景记忆的特定方面以及潜在的心理和神经过程。这篇综述总结了这些研究的结果，并讨论了AD当前和有前景的治疗方法对情景记忆的影响。这篇综述的目的是提高人们对认知神经科学家在理解完整和功能失调记忆方面所取得进展的认识。了解AD中受损的特定记忆过程可能对开发新疗法的基础科学家以及评估这些疗法疗效的临床研究人员具有巨大价值。
