下丘脑/穹窿深部脑刺激诱导的记忆增强。

Memory enhancement induced by hypothalamic/fornix deep brain stimulation.

作者信息

Hamani Clement, McAndrews Mary Pat, Cohn Melanie, Oh Michael, Zumsteg Dominik, Shapiro Colin M, Wennberg Richard A, Lozano Andres M

机构信息

Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada.

出版信息

Ann Neurol. 2008 Jan;63(1):119-23. doi: 10.1002/ana.21295.

DOI:10.1002/ana.21295

PMID:18232017

Abstract

Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double-blinded "on" versus "off" manner demonstrated that stimulation increased recollection but not familiarity-based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions.

摘要

对一名病态肥胖患者进行了双侧下丘脑深部脑刺激治疗。我们非常意外地观察到，刺激诱发了详细的自传体记忆。以双盲“开”与“关”的方式进行的联想记忆任务表明，刺激增强了回忆，但基于熟悉度的识别没有增强，这表明海马体的功能参与。脑电图源定位显示，下丘脑深部脑刺激驱动了内侧颞叶结构的活动。这表明该患者的下丘脑刺激调节了边缘系统活动并改善了某些记忆功能。